PI3K p110α Blockade Enhances Anti-Tumor Efficacy of Abemaciclib in Human Colorectal Cancer Cells.
Lee HJ, Kim KJ, Sung JH, Nam M, Suh KJ, Kim JW, Kim SH, Kim JW, Kim YJ, Lee KW, Lee JS, Kim JH.
Lee HJ, et al.
Cancers (Basel). 2020 Sep 3;12(9):2500. doi: 10.3390/cancers12092500.
Cancers (Basel). 2020.
PMID: 32899250
Free PMC article.
Abemaciclib/BYL719 combination therapy demonstrated synergistic effects regardless of PIK3CA mutation status but showed greater efficacy in the PIK3CA mutated SNU-C4 cell line. Growth inhibition, cell cycle arrest, and migration inhibition were confirmed as mechanisms of a …
Abemaciclib/BYL719 combination therapy demonstrated synergistic effects regardless of PIK3CA mutation status but showed greater efficacy in …